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Monday, 25 August 2014

Ebola: Experimental Therapies under development

Ebola Virus Disease (EVD) currently  presently have no approved cure and also no preventive vaccination. However there are currently some therapies under investigation. Unfortunately the trails of these therapies are not being done in presently heavy burdened countries like Liberia, Serrian Leone and Guinea.


1  Serum therapy

  •     One of   potential product is Zmapp. It was developed with U.S. military funding by a San Diego company, using antibodies harvested from lab animals injected with parts of the Ebola virus. It works by boosting immune system's efforts to fight the virus. It was recently used for US Doctor- Kent Brantly & Nancy Writebol who were both infected in Liberia while working for Samarita Purse. However the request by Nigeria Government to US government was refused.

  •   Infected patients are transfused with blood or plasma from patients who recently recovered from Ebola virus infection. This work based on premise that plasma from recovered patients contains life-saving antibodies. However results of such treatment have not been formally reported for human.

  •  Another compound – BCX4430 (RNA –dependent RNA polymerase inhibitor) reported in Nature journal 2014.It was proven successful in a non-human primate model(cynomolgus macaques) but no human trials reported yet.
Articles that may interest you(Just Click on Link)
      12 "things" about Ebola
      Where are the risk of Human Ebola transmission?

      HealthGuard



    Wednesday, 20 August 2014

    Where are the risk of Human Ebola transmission?

    Animal to human transmission
    ·         Infection through handling of infected chimpanzees, gorillas, fruit bats, monkeys, forest antelope & porcupines ( ill or dead)
    Chimpanzee
    Image courtesy of anankkml at FreeDigitalPhotos.net
    •               Such contact maybe through:
    1.       Hunters with animals
    2.       Consumption of such animals infected with the virus
    Fruit Bat
    Image courtesy of Hal Brindley at FreeDigitalPhotos.net
    Human-to-Human Transmission
    Disease spread   in human population through human-to-human transmission which maybe through direct contact with broken skin or mucous membranes with bodily fluids of infected people like vomit, stool, blood, urine so also with saliva, sweat, tears. Indirect contact with environments contaminated with such fluids and touching nostrils, eyes or mouth also constitute a risk.

    Other Articles that may interest you

    Thursday, 21 November 2013

    How to deal with a cold

    One of the best cold remedy usually is to rest and make the human body heal itself. However, there supplements to be found that can greatly decrease the amount of time from getting sick to full recovery. Many of these remedies are natural and might be applied too much methods of sicknesses. By way of a cold a number of symptoms can fallow. 
    Image courtesy of [David Castillo Dominici] / FreeDigitalPhotos.net

    There will be no 100% effective cures to help in the fastest way to get cleared of an ice pack. However, what you are able to do is work a challenge to get grow your immunity system who can reversibly fight the bacteria and cold. The best cold remedy ought to include rest and hydration alongside four powerful supplements to strengthen your immunity. These four supplements include:

    Vitamin C 
    Zinc
    Garlic
    E vitamin

    The truly amazing thing is these features can most likely show up along the home and are a naturally way to assist the body recover. But, what will they do and merely the whole lot so essential?
    Vitamin C- this vitamin haven t been proven to minimize sickness, however it is observed to decrease recovery time. It without a doubt will this by reducing inflammation and by adding fuel towards the immune system to feed along side.
    Zinc- zinc lozenges are so popular in the course of the cold since they help vanish the cold because of its mineral qualities.
    Garlic- There was studies to point out that garlic is ideal for presentation against colds in addition to reducing recovery time.
    Vitamin E- this happens to be another superb vitamin which has been known becoming a strong preventative against colds.

    These will help control and get rid of the cold along with symptoms. However, there are certain things you can do eliminate these individual symptoms. Alternative treatment methods for hyperthyroid symptoms and get a fever, along with supplements, should include the drinking a plenty of water and juice, cool baths, and wrapping up in a very very blanket for periods of your time. Home remedies for coughs should consist of Echinacea to decrease symptoms, peppermint tea to suppress the coughing reflex, to discover that the herb slippery elm which will help soothe the throat.

    The best cold remedy ought to be made up of a variety of rest, nutrients, water, and supplements. The goal often to produce body chance to increase its defense and restore itself. Some colds take a longer amount of time to when compared to others to get over. However, by fallowing simple steps you then should be healthy and walking while your friends remain sick on the couch.

    If you want more see fastestwaytogetridofacoldnow.com

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    Wednesday, 20 November 2013

    The Benefits of Slumber


    Why You Need a Good Night’s Sleep

    We have so many demands on our time—jobs, family, errands—not to mention finding some time to relax.
    To fit everything in, we often sacrifice sleep. But sleep affects both mental and physical health. It’s vital to your well-being.

    Of course, sleep helps you feel rested each day. But while you’re sleeping, your brain and body don’t just shut down. Internal organs and processes are hard at work throughout the night. 

    “Sleep services all aspects of our body in one way or another: molecular, energy balance, as well as intellectual function, alertness and mood,” says Dr. Merrill Mitler, a sleep expert and neuroscientist at NIH.
    When you’re tired, you can’t function at your best. Sleep helps you think more clearly, have quicker reflexes and focus better. “The fact is, when we look at well-rested people, they’re operating at a different level than people trying to get by on 1 or 2 hours less nightly sleep,” says Mitler.    
          
    “Loss of sleep impairs your higher levels of reasoning, problem-solving and attention to detail,” Mitler explains. Tired people tend to be less productive at work. They’re at a much higher risk for traffic accidents. Lack of sleep also influences your mood, which can affect how you interact with others. A sleep deficit over time can even put you at greater risk for developing depression.

    But sleep isn’t just essential for the brain. “Sleep affects almost every tissue in our bodies,” says Dr. Michael Twery, a sleep expert at NIH. “It affects growth and stress hormones, our immune system, appetite, breathing, blood pressure and cardiovascular health.”

    Research shows that lack of sleep increases the risk for obesity, heart disease and infections. Throughout the night, your heart rate, breathing rate and blood pressure rise and fall, a process that may be important for cardiovascular health. Your body releases hormones during sleep that help repair cells and control the body’s use of energy. These hormone changes can affect your body weight. 

    “Ongoing research shows a lack of sleep can produce diabetic-like conditions in otherwise healthy people,” says Mitler. 

    Recent studies also reveal that sleep can affect the efficiency of vaccinations. Twery described research showing that well-rested people who received the flu vaccine developed stronger protection against the illness.  

    A good night’s sleep consists of 4 to 5 sleep cycles. Each cycle includes periods of deep sleep and rapid eye movement (REM) sleep, when we dream. “As the night goes on, the portion of that cycle that is in REM sleep increases. It turns out that this pattern of cycling and progression is critical to the biology of sleep,” Twery says.

    Although personal needs vary, on average, adults need 7 to 8 hours of sleep per night. Babies typically sleep about 16 hours a day. Young children need at least 10 hours of sleep, while teenagers need at least 9 hours. To attain the maximum restorative benefits of sleep, getting a full night of quality sleep is important, says Twery. 

    Sleep can be disrupted by many things. Stimulants such as caffeine or certain medications can keep you up. Distractions such as electronics—especially the light from TVs, cell phones, tablets and e-readers—can prevent you from falling asleep.

    As people get older, they may not get enough sleep because of illness, medications or sleep disorders. By some estimates, about 70 million Americans of all ages suffer from chronic sleep problems. The 2 most common sleep disorders are insomnia and sleep apnea.

    People with insomnia have trouble falling or staying asleep. Anxiety about falling asleep often makes the condition worse. Most of us have occasional insomnia. But chronic insomnia—lasting at least 3 nights per week for more than a month—can trigger serious daytime problems such as exhaustion, irritability and difficulty concentrating.

    Common therapies include relaxation and deep-breathing techniques. Sometimes medicine is prescribed. But consult a doctor before trying even over-the-counter sleep pills, as they may leave you feeling unrefreshed in the morning.

    People with sleep apnea have a loud, uneven snore (although not everyone who snores has apnea). Breathing repeatedly stops or becomes shallow. If you have apnea, you’re not getting enough oxygen, and your brain disturbs your sleep to open your windpipe. 

    Apnea is dangerous. “There’s little air exchange for 10 seconds or more at a time,” explains Dr. Phyllis Zee, a sleep apnea expert at Northwestern University. “The oxygen goes down and the body’s fight or flight response is activated. Blood pressure spikes, your heart rate fluctuates and the brain wakes you up partially to start your breathing again. This creates stress.” 

    Apnea can leave you feeling tired and moody. You may have trouble thinking clearly. “Also, apnea affects the vessels that lead to the brain so there is a higher risk of stroke associated with it,” Zee adds.
    If you have mild sleep apnea, you might try sleeping on your side, exercising or losing weight to reduce symptoms. A CPAP machine, which pumps air into your throat to keep your airway open, can also help. Another treatment is a bite plate that moves the lower jaw forward. In some cases, however, people with sleep apnea need surgery. 

    “If you snore chronically and wake up choking or gasping for air, and feel that you’re sleepy during the day, tell your doctor and get evaluated,” Zee advises.
    NIH is currently funding several studies to gain deeper insights into sleep apnea and other aspects of sleep. One 5-year study of 10,000 pregnant women is designed to gauge the effects of apnea on the mother’s and baby’s health. Zee says this study will shed more light on apnea and the importance of treatment.
    Good sleep is critical to your health. To make each day a safe, productive one, take steps to make sure you regularly get a good night’s sleep.
    Source: NIH News in Health