Tuesday, 16 September 2014
Monday, 25 August 2014
Ebola: Experimental Therapies under development
Ebola Virus Disease (EVD) currently presently have no approved cure and also no preventive vaccination. However there are
currently some therapies under investigation. Unfortunately the trails of these therapies are not being done in presently heavy burdened countries like
Liberia, Serrian Leone and Guinea.
1 Serum
therapy
- One of potential product is Zmapp. It was developed with U.S. military funding by a San Diego company, using antibodies harvested from lab animals injected with parts of the Ebola virus. It works by boosting immune system's efforts to fight the virus. It was recently used for US Doctor- Kent Brantly & Nancy Writebol who were both infected in Liberia while working for Samarita Purse. However the request by Nigeria Government to US government was refused.
- Infected patients are transfused with blood or plasma from patients who recently recovered from Ebola virus infection. This work based on premise that plasma from recovered patients contains life-saving antibodies. However results of such treatment have not been formally reported for human.
- Another compound – BCX4430 (RNA –dependent RNA polymerase inhibitor) reported in Nature journal 2014.It was proven successful in a non-human primate model(cynomolgus macaques) but no human trials reported yet.
Where are the risk of Human Ebola transmission?
HealthGuard
Saturday, 23 August 2014
12 "things" about Ebola
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Wednesday, 20 August 2014
Where are the risk of Human Ebola transmission?
Animal to human
transmission
·
Infection through handling of infected
chimpanzees, gorillas, fruit bats, monkeys, forest antelope & porcupines (
ill or dead)
 |
| Chimpanzee Image courtesy of anankkml at FreeDigitalPhotos.net |
- Such contact maybe through:
1.
Hunters with animals
2.
Consumption of such animals infected with the
virus
 | |
| Fruit Bat Image courtesy of Hal Brindley at FreeDigitalPhotos.net |
Human-to-Human
Transmission
Disease spread in
human population through human-to-human transmission which maybe through direct
contact with broken skin or mucous membranes with bodily fluids of infected
people like vomit, stool, blood, urine so also with saliva, sweat, tears. Indirect
contact with environments contaminated with such fluids and touching nostrils,
eyes or mouth also constitute a risk.
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